Improving biosensing activity to carcinoembryonic antigen with orientated single domain antibodies
نویسندگان
چکیده
منابع مشابه
Improving biosensing activity to carcinoembryonic antigen with orientated single domain antibodies
Carcinoembryonic antigen (CEA), also referred as CEACAM5, is integral to the adhesion process during cancer invasion and metastasis and is one of the most widely used tumor markers for assisting the diagnosis of cancer recurrence and cancer metastasis. Antibodies against CEA molecules have been developed for detection and diagnostic applications following tumor removal. Single domain antibodies...
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Localized surface plasmon resonance (LSPR) spectroscopy and imaging are emerging biosensor technologies which tout label-free biomolecule detection at the nanoscale and ease of integration with standard microscopy setups. The applicability of these techniques can be limited by the restrictions that surface-conjugated ligands must be both sufficiently small and orientated to meet analyte sensiti...
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Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction imaging. In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successf...
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Upper- and lower-extremity lymphoscintigraphy was performed on 50 patients with proven carcinoma of the breast, gastrointestinal system, genitourinary tract, lung, and vulva; 42 patients had 131I-antibodies to carcinoembryonic antigen (CEA) and 8 patients had 131I-normal goat immunoglobulin G. All metastases in the axillary or inguinal lymph nodes were detected with the CEA antibodies. In nine ...
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We previously demonstrated that patients with carcinoembryonic antigen [CEA]-producing neoplastic tumors, treated with murine monoclonal antibody to CEA, produced antibodies directed against the constant regions [human anti-mouse antibody (HAMA)] and the idiotypes [anti-Id] of these murine immunoglobulins. In this study, we describe a method for analyzing the presence of such antibodies in the ...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2017
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2017.e00478